AB1519 NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO AS POTENTIAL MARKERS FOR DISEASE ACTIVITY EVALUATION IN BEHCET’S DISEASE

Background Behcet’s disease (BD) is an auto-inflammatory disorder, characterized by recurrent aphthous stomatitis, genital ulcers, uveitis, erythema nodosum and other numerous mucocutaneous, gastrointestinal, neurological, vascular manifestations. Despite many biomarkers (anti-lysozyme, serum endocan, alpha 1-acid glycoprotein (AGP)) have been investigated for evaluating activity predicting severity, none of mentioned above accessibility to be used in clinical routine. During recent years neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) proposed as easy countable markers severe inflammation endothelial injury therefor can the assessment activity. Objectives The aim this study analyze potential role NLR PLR Methods 62 patients with (76,4% male 23,6 % female) 56 healthy controls were included study. Patients Behcet fulfilled International Criteria (ICBD 2006). Disease was assessed Clinical Activity Form (BDCAF). All at moment had active disease. Participants from control group didn’t present any history cardiac or endocrine disease, because conditions also cause high levels PLR. Results mean age patient 36±11,2 years. oral ulcers episode 82,26% nodosum, 61,29% -genital ulcers. 40,38%- eye lesions, 0,05%-entero-Behcet, 0,032%- neuro-Behcet. According our study, positively correlate BDCAF score (r=0.401, p<0.01) CRP (r=0,571, p<0,01), while there no correlation found between Levels both significantly higher compare (p<0,001 p<0,05 accordingly). Conclusion Taking into consideration data could implemented practice a cheap accessible marker On hand, further studies bigger samples are required evaluate changes BD. Assessment among BD remission find out if compared controls. References [1]Rifaioglu EN, Bülbül Sen B, Ekiz Ö, Cigdem Dogramaci A. Neutrophil lymphocyte Behçet’s Acta Dermatovenerol Alp Pannonica Adriat. 2014;23(4):65–67. [2]Macey M, Hagi-Pavli E, Stewart J, Wallace GR, Stanford Shirlaw P, Fortune F (2011) Age, gender disease-related platelet neutrophil activation ex vivo whole blood Rheumatology 50(10):1849–1859 [3]Alan S, Tuna Türkoğlu EB (2015) relation ratio, volume presence severity syndrome. Kaohsiung J Med Sci 31:626e631 Acknowledgements: NIL. Disclosure Interests None Declared.